Effect of Endogenous Melatonin Hormone on Cardiovascular System: A Review of Literature

Melatonin (MLT) "N-acetyl-5-methoxytryptamine"; a pineal hormone; has diurnal variation and may be necessary for the suprachiasmatic nucleus (SCN) peripheral tissue's molecular circadian clocks to synchronized, powerful receptor-dependent receptor-independent effects on number of cardiovascular (CV) variables, including endothelial cells function, thrombus formation, blood pressure (BP), heart rate (HR). MLT possesses antioxidative, anti-inflammatory, chronobiotic, perhaps epigenetics regulatory characteristics. Low concentrations have been found in persons who coronary artery disease (CAD), arterial hypertension (HT), congestive cardiac failure. The physiological function endogenous its rhythm human CV system is reviewed this article.